F35. GENE EXPRESSION SUGGEST ALTERED GLUTAMATERGIC, DOPAMINERGIC AND ESTROGEN CLASSICAL PATHWAYS IN WORKING MEMORY DEFICIT IN SCHIZOPHRENIA
نویسندگان
چکیده
منابع مشابه
Working memory deficit as a core neuropsychological dysfunction in schizophrenia.
OBJECTIVE This study tested the hypothesis that impaired working memory is a core deficit underlying multiple neuropsychological deficits in schizophrenia patients. METHOD The subjects were 27 men with stable chronic schizophrenia treated with atypical antipsychotics and 38 normal participants. They were assessed with a battery of neuropsychological tests. Verbal working memory was measured w...
متن کاملHemispheric asymmetry of spatial working memory deficit in schizophrenia.
Spatial working memory function was assessed in schizophrenia patients, hypothetically 'psychosis-prone' individuals who report unusual perceptual experiences and normal control subjects with an oculomotor delayed response task. Past studies point to the important role of dorsolateral prefrontal system in spatial working memory deficits of schizophrenia patients. In order to better understand t...
متن کاملVerbal Memory and Working Memory Impairment in Healthy Siblings of Patients with Schizophrenia
Objective: This study aimed to investigate the verbal memory and working memory impairment in healthy siblings of patients with schizophrenia. Methods: The purpose of this study was to compare cognitive deficits in siblings of the patients with schizophrenia and control group. A total of 35 unaffected siblings of patients with schizophrenia were selected from the relatives of the pat...
متن کاملMicroRNAs suggest a new mechanism for altered brain gene expression in schizophrenia.
N europharmacologic and genetic association studies implicate dysregulation of NMDA receptor function in the pathophysiology of schizophrenia and bipolar disorder (1). In this issue of PNAS Kocerha et al. (2) suggest a novel molecular mechanism whereby a microRNA (miRNA) regulates signaling downstream from the NMDA receptor at the calcium/ calmodulin-dependent protein kinase II subunit (CaMKII ...
متن کاملDopaminergic and Glutamatergic Dysfunctions in the Neuropathophysiology of Schizophrenia
Schizophrenia is a devastating mental disorder that affects almost 1% of the human population. Although the etiology and fundamental pathological processes associated with schizophrenia remain unclear, abnormalities of the dopamine and glutamate systems have been implicated in their occurrence. The putative role of dopamine in the pathophysiology and treatment of schizophrenia has been studied ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2019
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbz018.447